A Bayesian feature allocation model for tumor heterogeneity
نویسندگان
چکیده
منابع مشابه
A Bayesian feature allocation model for tumor heterogeneity
We develop a feature allocation model for inference on genetic tumor variation using next-generation sequencing data. Specifically, we record single nucleotide variants (SNVs) based on short reads mapped to human reference genome and characterize tumor heterogeneity by latent haplotypes defined as a scaffold of SNVs on the same homologous genome. For multiple samples from a single tumor, assumi...
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ژورنال
عنوان ژورنال: The Annals of Applied Statistics
سال: 2015
ISSN: 1932-6157
DOI: 10.1214/15-aoas817